Jung, Michael E,Sawyers, Charles L,Ouk, Samedy,Tran, Chris,Wongvipat, John
申请号：
ES13178051
公开号：
ES2588606T3
申请日:
2007.03.27
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound according to formula II ** Formula ** or a pharmaceutically acceptable salt thereof, wherein A and B are independently selected from oxygen and sulfur, wherein R1 is selected from aryl and substituted aryl, in which R2 and R3, together with the carbon to which they are attached, form a substituted cycloalkyl or cycloalkyl, in which R4, R5, R6, and R7 are independently selected from the group consisting of hydrogen, halogenated alkyl, CN, alkyl, alkyl substituted, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, arylalkyl, arylalkenyl, arylalkyl, halogenated alkenyl, halogenated alkynyl, halogen, NO2, OR11, SR11 NR11R12, NH (CO) OR11, NH (CO) NR11R12 NR12 (CO) R11, O (CO) R11, O (CO) OR11, O (CS) R11, NR12 (CS) R11 NH (CS) NR11R12, and NR12 (CS) OR11, in which R11 and R12 are selected independently between hydrogen, alkyl, substituted alkyl, alkenyl or substituted alkenyl, alkynyl or alkynyl su stituido, aryl, substituted aryl, arylalkyl, arylalkenyl, arylalkyl, aromatic or non-aromatic heterocyclic or substituted aromatic or non-aromatic heterocyclic in which R11 and R12 can be connected to form a cycle that may be aromatic or non-aromatic heterocyclic or substituted aromatic heterocyclic, wherein each substituted alkyl is independently substituted with one or more groups selected from the hydroxyl, bromine, fluorine, chlorine, iodine, mercapto or uncle, cyano, alkylthio, heterocyclyl, aryl, heteroaryl, carboxyl, carbalcoyl, alkyl, alkenyl groups, nitro, amino, alkoxy and amido； each substituted cycloalkyl is independently substituted with one or more groups selected from the groups alkyl, alkoxy, hydroxy, aryl, aryloxy, arylalkyl, cycloalkyl, alkylamido, alkanoylamino, oxy, acyl, arylcarbonylamino, amino, nitro, cyano, thiol, alkylthio, bromine , fluorine, chlorine, iodine, heterocyclyl, heteroaryl, carboxyl, carbalcoyl, alkenyl and amido； each substituted alkenyl is independently substituted with one or more groups sel
