(EN) substituted 2-amino-3-sulfonyl-pyrazolo[1,5-A] pyrimidines/antagonists of serotonin 5-HT6 receptors, methods for the production and the use thereof
Nikolay Filippovich Savchuk;Alexander Vasilievich Ivashchenko
发明人:
Nikolay Filippovich Savchuk,Alexander Vasilievich Ivashchenko
申请号：
US12812733
公开号：
US08309559B2
申请日:
2009.01.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to novel substituted 2-amino-3-(arylsulfonyl)pyrazolo[1,5-a]pyrimidines of general formula 1, to serotonin 5-HT6 receptor antagonists, to novel drug substances and pharmaceutical compositions, to medicaments, methods for preparation thereof, and to methods for prophylaxis and treatment of various CNS diseases, pathogenesis of which is associated with disturbance of monoaminergic signaling pathways, more specifically over- or hypo-activation of serotonin 5-HT6 receptors.Ar represents optionally substituted aryl or optionally substituted heterocyclyl； R1 and R3 independently of each other represent C1-C3 alkyl or aryl； R2 represents hydrogen or C1-C3 alkyl； R41, and R42 independently of each other represent hydrogen, optionally substituted C1-C3 alkyl or optionally substituted phenyl, or R41, and R42 together with nitrogen atom they are attached to form optionally substituted heterocyclyl.
