UTILISATION DE LECTINE EXTRAITE DE FÈVES VELOUTÉES POUR AUGMENTER L'ABONDANCE DE CELLULES SOUCHES HÉMATOPOÏÉTIQUES ET DE CELLULES PROGÉNITRICES DANS LA MOELLE OSSEUSE ET/OU DE CELLULES SOUCHES ÉPIDERMIQUES DANS LA PEAU IN VIVO
Use of Jack Bean lectin or a pharmaceutically acceptable salt thereof for increasing the abundance of hematopoietic stem cells and progenitor cells in bone marrow and/or epidermal stem cells in skin in vivo and a method of treatment involving the said lectin at a specific dose to treat conditions due to depletion of stem cells. Method of treating said conditions in a subject by administering a single injection of lectin dose 0.5-2.0 mg / kg body weight to mouse increasing the abundance of skin stem cells to 8.097 ± 0.938 % to 9.993 ± 0.542 % in mice treated with lectin dose of 0.5 mg /kg body weight and 2 mg/kg body weight respectively from 2.815 ± 0.100 % (mean ± SEM) in control untreated mice； and a dose range 8.0-10 mg / kg body weight to mouse for increasing the abundance of hematopoietic stem cells in bone marrow in control untreated mice with 0.293 ± 0.043 % (mean ± SEM) to 1.956 ± 0.592 % and 0.692 ± 0.193 % in mice treated with lectin dose of 8.0 mg /kg body weight and 10 mg/kg body weight respectively.
