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Novel Angiopoietin 2, VEGF Dual Antagonists
专利权人:
Jiangsu Aosaikang Pharmaceutical Co., Ltd.;AskGene Pharma Inc.
发明人:
Yuefeng Lu,Jian-Feng Lu
申请号:
US15593280
公开号:
US20170327569A1
申请日:
2017.05.11
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present disclosure relates to chimeric molecules which are fusion proteins comprising two components: an Ang-2 binding peptide linked to either a VEGF antibody or a VEGF receptor-Fc fusion protein. The Ang2 peptide, VEGF antibody, and VEGF receptor-Fc fusion proteins are each defined below with reference to percent identity to a reference sequence. The chimeric molecule is a fusion protein, dual antagonist of Ang2 and VEGF for treatment of cancers, proliferative retinopathies, neovascular glaucoma, macular edema, AMD, and rheumatoid arthritis.
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