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CONSTRUCTIONS MULTIMERIQUES
专利权人:
GENZYME CORPORATION
发明人:
申请号:
EP05810409.2
公开号:
EP1804835B9
申请日:
2005.09.13
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
Multimeric fusion proteins of an Ig-like domain of Flt-1 are rendered functional by inclusion or a linker moiety. Vectors encoding the fusion proteins and host cells expressing the fusion proteins can be used therapeutically to block neovascularization in individuals with pathological conditions related to neovascularization. Such conditions include age-related macular degeneration, cancer, psoriasis, proliferative diabetic retinopathy, asthma, uveitis, osteoarthritis, and rheumatoid arthritis. The same means of multimerization used for an lg-like domain of Flt-1, i . e ., a linker and a multimerization domain, can be used for other polypeptides, including extracellular receptors, antibody variable regions, cytokines, chemokines, and growth factors.
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