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Enantiomeric resolution of 2,4-disubstituted 1,3-oxathiolane nucleosides
专利权人:
シャイアー カナダ インコーポレイテッド
发明人:
ダン・サイモン,ドラゴス・ヴィジティウ,ジャン-エリック・ラコステ,ジャン-エリック・ラコステ
申请号:
JP2011525634
公开号:
JP5690731B2
申请日:
2008.09.05
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
Single enantionmers of compounds of formula (B), in either the cis or trans configuration, wherein R1 and R2 are as defined herein, can be separated from enantiomeric mixtures thereof by reacting the compound with an acid to produce a conglomerate salt that has the following characteristics: the IR spectrum of the salt of the racemic compound, a 1:1 mixture of (−) and (+) crystals, is identical to that of the each of the single enantiomer, and the salt of the racemic compound has a melting point lower that that of either single enantiomer. The conglomerate salt is then separated by preferential crystallization.
来源网站:
中国工程科技知识中心
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