BRAIN, CHRISTOPHER THOMAS,CHO, YOUNG SHIN,GIRALDES, JOHN WILLIAM,LAGU, BHARAT,LEVELL, JULIAN,LUZZIO, MICHAEL,PEREZ, LAWRENCE BLAS,WANG, YAPING,YANG, FAN
申请号：
ES11707115
公开号：
ES2548532T3
申请日:
2011.02.17
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound according to formula (I) ** ** Formula wherein: R1 is C3-7 alkyl C4-7 cycloalkyl optionally substituted with a substituent selected from the group consisting of C1-6 alkyl and OH phenyl optionally substituted with a substituent selected from the group consisting of C1-6 alkyl, C (CH3) 2 CN, and OH piperidinyl optionally substituted with cyclopropyl or C1-6 alkyl tetrahydropyranyl optionally substituted with C1-6 alkyl or cyclopropyl or bicyclo [2.2.1] heptanyl A is CH or N R11 is hydrogen or C1-4 alkyl L is a bond, C (O), or S (O) 2 R2Y is ** ** Formula V is NH or CH2 X is O or CH2 W is O or NH m and n are each independently 1, 2, or 3 with the proviso that m and n are not both 3 R2Y each is optionally substituted with one to four substituents each independently selected from the group consisting of: C1-3 alkyl optionally substituted with one to two substituents each independently selected from the group consisting of hydroxy, NH2, and -S-C1- 3 alkyl CD3 halo oxo C1-3 haloalkyl hydroxy NH2 dimethylamino benzyl -C (O) -C1-3alquilo optionally substituted with one to two substituents each independently selected from the group consisting of NH2 -SCH3 and NHC (O) CH3 - S (O) 2-C1-4 alkyl and pyrrolidinyl-C (O) - R4 is hydrogen, deuterium, or C (R5) (R6) (R7) and R5, R6, R7, R8, R9 and R10 are each independently H or deuterium or a pharmaceutically acceptable salt thereof.Un compuesto de acuerdo con la fórmula (I)**Fórmula** en donde: R1 es C3-7 alquilo C4-7 cicloalquilo opcionalmente sustituido con un sustituyente seleccionado del grupo que consiste de C1-6 alquilo y OH fenilo opcionalmente sustituido con un sustituyente seleccionado del grupo que consiste de C1-6 alquilo, C(CH3)2CN, y OH piperidinilo opcionalmente sustituido con un ciclopropilo o C1-6 alquilo tetrahidropiranilo opcionalmente sustituido con un ciclopropilo o C1-6 alquilo o biciclo[2.2.1]heptanilo A es CH o N R11 es hidrógeno o C1-4 alquilo L es un enlace, C(O), o S(O)2 R2Y es**Fórmula** V es N
