JUERGEN WICHMANN,RAINER E. MARTIN,JENS-UWE PETERS,SIMONA M. CECCARELLI,RAVI JAGASIA,ROLAND JAKOB-ROETNE
申请号：
MX2015006364
公开号：
MX2015006364A
申请日:
2013.11.18
申请国别(地区):
MX
年份:
2015
代理人:
摘要：
The present invention relates to the use of compounds of general formula (I) wherein R is hydrogen or lower alkyl R1 is halogen, lower alkyl, cycloalkyl or cyano or is phenyl, optionally substituted by one to three substituents, selected from lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen, halogen, cyano, hydroxy, C(O)-NH-lower alkyl, CH2-C(O)-NH-lower alkyl, CH2-NH-C(O)-lower alkyl, CH2NH2, S(O)2CH3, S(O)2N(CH3)2, or by heterocycloalkyl groups or is pyrazol-1, 4 or 5-yl, optionally substituted by lower alkyl or is thiazol-5-yl, optionally substituted by one or two lower alkyl groups or is pyridine 2, 3 or 4-yl, optionally substituted by lower alkyl, lower alkoxy, halogen or N(CH3)2 or is 3,6-dihydro-2H-pyran or is benzo[d][1,3]dioxol-5-yl or is 2,3-dihydrobenzo[b][1,4]dioxin-6-yl R2 is hydrogen, lower alkyl or lower alkyl substituted by alkoxy R3 is hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy, NH-S(O)2-CH3, -(CH2)m-O-lower alkyl or -(CH2)n-S(O)2-CH3 or is -(CR2)n-phenyl, optionally substituted by -S(O)2CH3 or lower alkoxy or is -(CH2)n-heterocycloalkyl, optionally substituted by lower alkyl and =O or is -(CH2)n-heteroaryl, optionally substituted by one or two lower alkyl groups or is -(CH2)n-cycloalkyl, optionally substituted by cyano or R2 and R3 form together with the N atom to which they are attached a heterocyclic ring, selected from morpholine, piperidine, 1, 1-dioxo-thiomorpholine or piperazine which may be substituted by lower alkyl or C(O)O-lower alkyl, or may form a pyrrolidine ring, optionally substituted by hydroxy R is independently from n hydrogen or lower alkyl n is 0, 1, 2, 3 m is 2 or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof, for the treatment of schizophrenia, obsessive-compulsive personality disorder, depression, bipolar disorders, anxiety disorders,
