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CARBOCYCLIC GLYT1 RECEPTOR ANTAGONISTS
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
KOLCZEWSKI, SABINE,PINARD, EMMANUEL
申请号:
SG2012013439
公开号:
SG178576A1
申请日:
2010.08.24
申请国别(地区):
SG
年份:
2012
代理人:
摘要:
The present invention relates to the use of a compound of general formula (I) wherein R1/R2 are independently from each other hydrogen, lower alkyl, -CH2)o-cycloalkyl for o being 0 or 1, or are benzyl or heterocycloalkyl or R1 and R2 are together with the N-atom to which they are attached a ring containing -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)2-O-(CH2)2-, -(CH2)2-S-(CH2)2-, -(CH2)2-NR-(CH2)2-, -(CH2)2-C(O)-(CH2)2-, -(CH2)2-CF2-(CH2)2-, -CH2-CHR-(CH2)2, -CHR-(CH2)3, CHR-(CH2)2-CHR-, or is the ring 2,6-diaza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester and R is hydroxy, halogen, cycloalkyl, or C(O)O-lower alkyl X is -(CH2)4-, -(CH2)3-, -(CH2)2- or -CH2- R3 is S-lower alkyl, CF3, OCHF2, lower alkoxy, lower alkyl, phenyl, cycloalkyl or halogen R4 is CF3, lower alkoxy, lower alkyl, halogen and n is 1 or 2 or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomers and/or optical isomers thereof for the manufacture of a medicament for the treatment of psychoses, pain, dysfunction in memory and learning, attention deficit, schizophrenia, dementia disorders or Alzheimers disease.
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