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NEO-ANTIGEN SPECIFIC T CELLS
专利权人:
CANCER RESEARCH TECHNOLOGY LIMITED
发明人:
Nicholas McGranahan,Rachel Rosenthal,Charles Swanton,Karl Peggs,Sergio Quezada
申请号:
US16565350
公开号:
US20200000904A1
申请日:
2019.09.09
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to a method for identifying a truncal neo-antigen in a tumour from a subject which comprises the steps of: i) determining mutations present in a sample isolated from the tumour; and ii) identifying a truncal mutation which is a mutation present in essentially all tumour cells; and iii) identifying a truncal neo-antigen, which is an antigen encoded by a sequence which comprises the truncal mutation.
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