David Knaack,Michele Diegmann,Albert Manrique,Keyvan Benham
申请号：
US10589226
公开号：
US08333985B2
申请日:
2005.01.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A demineralized bone matrix (DBM) or other matrix composition is provided that has been stabilized by lowering the pH of the composition, reducing the water content, adding water substitutes, and/or increasing the amount of deuterated water present in the composition in order to reduce the activity of endogenous degrading enzymes such as proteases. A hydrated form of a stabilized DBM composition may be stable up to a year at room temperature at acidic pH. The acidified DBM compositions may be further stabilized by the addition of a stabilizing agent such as deuterated water, water substitutes, polymers, protease inhibitors, glycerol or hydrogels.
