A method for promoting expression of insulin receptor substrate-2, comprising administering an effective amount of plasminogen to a subject. Also provided is a drug for promoting expression of insulin receptor substrate-2.本發明涉及一種促進胰島素受體底物-2表達的方法,包括給藥受試者有效量的纖溶酶原,同時本發明涉及用於促進胰島素受體底物-2表達的藥物。