NTricyclic chemical modulators of FOXO transcription factor proteins are disclosed. The compounds are useful to treat cancer age onset proteotoxicity stress induced depression inflammation and acne. The compounds are of the following and similar genera (i) (ii) and (iii) in which Het is an aromatic heterocyclic ring and Y is a point of attachment of various side chains and rings. An example of such a compound is 4 chloro (3 (10 11 dihydro 5H benzo[b]pyrido[2 3 f]azepin 5 yl)propyl)benzenesulfonamide (iv).
