Tricyclic heterocycles as anticancer agents

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专利权人:

Icahn School of Medicine at Mount Sinai

发明人:

Ohlmeyer, Michael,Kastrinsky, David

申请号：

AU2014219042

公开号：

AU2014219042A1

申请日:

2014.02.19

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

Tricyclic chemical modulators of FOXO transcription factor proteins are disclosed. The compounds are useful to treat cancer, age-onset proteotoxicity, stress-induced depression, inflammation, and acne. The compounds are of the following and similar genera (i), (ii) and (iii), in which Het is an aromatic heterocyclic ring and Y is a point of attachment of various side chains and rings. An example of such a compound is 4-chloro-

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