#$%^&*AU2015201727B220180308.pdf#####ABSTRACT The invention features compositions and methods for treating or preventing a neoplasia- More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatic (e.g, disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal fil), - 139a-