HELMUT FIEBIG,ANDREAS NANDY,ROLAND SUCK,OLIVER CROMWELL,ARND PETERSEN,WOLF-MEINHARD BECKER
申请号：
US13034210
公开号：
US20120288526A1
申请日:
2011.02.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for the in vitro and in vivo diagnosis of pollen allergies.
