A negative pressure wound therapy (NPWT) system creates and maintains a sub-atmospheric pressure within a sealed wound environment for the purpose of healing wounds. The NPWT system includes a wound interface material, a housing, an osmotic membrane, and an evacuation port. The wound interface material contacts a wound region and absorbs exudate from the wound region. The housing defines a cavity in an interior space of the housing. The osmotic membrane is coupled to the wound interface material to transfer a fluid of the exudate from the wound interface material to the cavity of the housing. The evacuation port is also coupled to the wound interface material to facilitate passage of a gas out of the wound interface material to create a negative pressure at the wound region.