Dong-Jin Kim,Chang-Hui Koo,II-Hee Cho,Sung-Bae Lee,Dong-Hoon Han
申请号：
US15521164
公开号：
US20170354668A1
申请日:
2015.05.19
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a synthesis method of preventing the formation of impurities and byproducts in the synthesis of tenofovir disoproxil fumarate (Teno-DF) used as a medicine for hepatitis B and HIV treatment due to its function to promote bioactivities. In the synthesis method of the present invention, an ion-exchange resin (Dowex 50W hydrogen form, sulfonic acidic cation exchange resin) is used to enhance the yield and purity of the compound. The present invention also relates to a method of preparing an oral dissolving film dosage form in the manufacture of a medicine using the tenofovir compound with high purity obtained by the synthesis method of the present invention as an effective ingredient.
