ОГБОРН Стивен Мартин (AU),ТОМАС Дэвид (GB),МОУЗЛИ Райан (GB),ЭЙЛУАРД Джеймс Харрисон (AU)
申请号：
RU2011137530/15
公开号：
RU2011137530A
申请日:
2010.02.12
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method of treating naturally aging and / or photo aging skin in a subject, comprising introducing an ingenol derivative or a pharmaceutically acceptable salt thereof into the skin of said subject. The method of claim 1, wherein the ingenol derivative has the formula: wherein R-R is independently selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted acyl, optionally substituted aryl, optionally substituted arylalkyl, S (O) R ', S (O) OR', P (O) (OR ') (where R' represents hydrogen, alkyl, alkenyl, alkynyl, acyl, aryl or arylalkyl) and glycosyl, or R and R or R and R may form a methylene or ethylene chain ； and R is selected from hydrogen, hydroxy, optionally substituted alkoxy, optionally substituted alkenoxy, optionally substituted alkynoxy, optionally substituted acyloxy, optionally substituted arylalkoxy, OS (O) R ', OS (O) OR', OP (O) (OR ') (where R 'represents hydrogen, alkyl, alkenyl, alkynyl, acyl, aryl or arylalkyl) and glyoxy. 3. The method according to claim 2, in which R represents an angelo group. The method according to claim 3, wherein the ingenol derivative is selected from the group consisting of ingenol-3-angelate, 20-O-acetyl-ingenol-3-angelate and 20-deoxy-ingenol-3-angelate. The method of claim 4, wherein the ingenol derivative is ingenol-3-angelate. The method according to claim 1, wherein the ingenol derivative is administered to the skin at least 10 cm. The method of claim 1, wherein the ingenol derivative is administered to the face, and / or neck, and / or throat, and / or region around the eyes. The method of claim 1, wherein the ingenol derivative is topically administered to the skin. The method according to claim 1, where the ingenol derivative is introduced in the form of a gel based on1. Способ лечения естественно стареющей и/или фотостареющей кожи у субъекта, включающий введение в кожу указанного субъекта производного ингенола или его фармацевт
