#$%^&*AU2015238924A120151029.pdf#####H: aar lnterwoven NRPortbl DCCAAR 8622548_1.do-10/12/2015 - 80 ABSTRACT One embodiment described herein is related to methods and compositions, such as nutraceutical formulations and dietary supplements, comprising C 16: 1n7-palmitoleate or derivatives thereof. The methods and compositions comprising C16: 1n7-palmitoleate, or derivatives thereof, safely and effectively prevent or mitigate manifestations of cardiovascular disease, including coronary artery disease and the accumulation of cholesterol or lipid deposits in the blood vessels of a subject.