#$%^&*AU2019264531A120191205.pdf#####l:1 aar Interoven NRPortbl DCC AAR 8622548_l.doc-I0/12/2015 ABSTRACT One embodiment described herein is related to methods and compositions, such as nutraceutical formulations and dietary supplements, comprising C16:1n7-palmitoleate or derivatives thereof. The methods and compositions comprising C16:1n7-palmitoleate, or derivatives thereof, safely and effectively prevent or mitigate manifestations of cardiovascular disease, including coronary artery disease and the accumulation of cholesterol or lipid deposits in the blood vessels of a subject.