Calmangafodipir, a new chemical entity, and other mixed metal complexes, methods of preparation, compositions, and methods of treatment

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专利权人:

PledPharma AB

发明人:

Jan-Olof Karlsson,Karl Reineke,Tino Kurz,Rolf Andersson,Michael Hall,Christina McLaughlin,Sven Jacobsson,Jacques Näsström

申请号：

US14369153

公开号：

US09187509B2

申请日:

2012.12.04

申请国别(地区):

US

年份:

2015

代理人:

摘要：

A mixed metal complex of a compound of Formula I, or a salt thereof, wherein the mixed metals comprise a Group III-XII transition metal and a Group II metal:wherein X, R1, R2, R3, and R4 are as defined herein, is produced in a one step crystallization from a solution of the Group III-XII transition metal, the Group II metal, and a compound of Formula I. Methods for treatment of a pathological condition in a patient, for example, a pathological condition caused by the presence of oxygen-derived free radicals, comprise administering the mixed metal complex to the patient.

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