Oxazolidinone containing dimer compounds, compositions and methods to make and use

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专利权人:

MERCK SHARP & DOHME CORP.

发明人:

HESTER D KEITH,DUGUID ROBERT J,FINN JOHN

申请号：

NZ62055210

公开号：

NZ620552A

申请日:

2010.05.27

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Disclosed are phosphate-containing dimers of (5R)-3-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-(hydroxymethyl)-2-oxazolidinone, having antibiotic activity in vivo upon cleaving, wherein M is OR1 wherein R1 is H, or a pharmaceutically acceptable cation. Also disclosed are compositions comprising such compounds and also the use of such for treating or preventing an bacterial infection.

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