CENTRO DE INVESTIGACIÓN CIENTÍFICA DE YUCATÁN; A.C.
发明人:
Rocío De Lourdes BORGES ARGÁEZ,Lisseth Abigail CETINA MONTEJO,Guadalupe AYORA TALAVERA
申请号：
MX2017000486
公开号：
MX2017000486A
申请日:
2017.01.11
申请国别(地区):
MX
年份:
2018
代理人:
摘要：
Influenza viruses are one of the main pathogens that cause respiratory diseases affecting millions of people around the world, having a high percentage of morbidity and mortality. These viruses can be controlled by vaccination and antivirals. Regarding the latter, only two main types of antivirals are approved by the FDA: 1) inhibitors of the M2 ion channel and 2) Neuraminidase inhibitors. However, the rapid resistance emergence limits its effectiveness. Due to this, the search for structural compounds and novel activity against these viruses has been spread. Naphthoquinones represent an excellent study group, since a lot of activities have been reported: antibacterial, antifungal, anti-inflammatory, anticarcinogenic and antiviral despite this, the anti-influenza activity is practically unexplored. In the present invention, the use of a dimeric naphthoquinone and its derivatives is described for the treatment and prevention of viral infections caused by viruses of the Ortomixoviridae family, particularly the influenza virus, presenting in its anti-influenza activity, a different mechanism to the neuraminidase inhibitors.Los virus de influenza son uno de los principales patógenos que causan enfermedad respiratoria afectando a millones de personas en todo el mundo, teniendo un alto porcentaje de morbilidad y mortalidad. Estos virus pueden ser controlados por vacunación y antivirales. Respecto a estos últimos, solamente están aprobados por la FDA dos tipos principales de antivirales: 1) los inhibidores del canal iónico M2 y 2) los inhibidores de la neuraminidasa. Sin embargo, la rápida aparición de resistencia limita su eficacia. Debido a esto, se ha extendido la búsqueda de compuestos de estructura y actividad novedosa contra estos virus. Las naftoquinonas representan un grupo excelente de estudio, ya que se han reportado una gran cantidad de actividades como antibacterial, antimicótica, antiinflamatoria, anticancerigena y antiviral, a pesar de ello la actividad anti-
