The synthesis of these drugs, their combinations, and their use as drugs, especially in the treatment of Alzheimer's disease or diabetes, using BACE-1 or bace-2.requirement 1: a formula compound (1),or a pharmaceutically acceptable salt thereof, in which any one, between X1 is CR1 or N； X3 is CR3 or N； X4 is CR4 or N； X5 is CR5 or N； wherein at least one of X1, X3, X4 and X5 is N and no more than 2 between X1, X3, X4 and X5 are N； or X1 is CR1 or N； X3 is CR3, N or S； X4 is a link； X5 is CR5, N or S； wherein at least one of X1, X3 and X5 is N or S, no more than 2 between X1, X3 and X5 are N and no more than 1 between X3 and X5 are S； R1 is hydrogen, cyano, halogen, C1-8 alkyl, halogen-C1-8 alkyl, C1-8 alkoxy, halogen-C1-8 alkoxy, C1-8 alkylthio, halogen C1-8 alkylthio, C1-8 alkoxy C1-8, C1-8 alkoxy-C1-8 alkoxy, C1-8 alkoxy-C1-8 alkylthio, C1-8 alkylthio-C1-8 alkyl,C1-8-alcoxyl c1-8, c1-8-asphaltc1-8-asphaltc1-8, alquenilo C2-8, or C2-8, or c2-8-asphalts； R2 is a G1 arilo group consisting of non aromatic heterocycles or heterocycles, optionally replaced by 1, 2, 3, or 4 independently selected substitutes from the group, including cyanogen, amino, amino, amino, amino asphalt-c1-8, N - (L) 1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1-1 c1-8-alcoxyl c1-8,C 1-8 alkoxy-C 1-8 alkylthio, C 1-8 alkylthio-C 1-8 alkyl, C 1-8 alkylthio-C 1-8 alkoxy, C 1-8 alkylthio-C 1-8 alkylthio, C2-8 alkenyl, C2-8 alkynyl, C2-8 alkenoxy, C2-8 alkyloxy and a C2-8 cycloalkyl group, aryl, heteroaryl or non-aromatic heterocyclic, such group G2 is optionally substituted by 1, 2, 3, or 4 substituents independently selected from the group, which consists of cyano, aminocarbonyl, halogen, C1-8 alkyl, halogen-C1-8 alkyl, hydroxyl, C1-8 alkoxy, halogen-C1-8 alkoxy, C1-8 alkylthio, halogen-C1-8 alkylthio, C1-8 alkoxy -C 1-8 alkyl, C 1-8 alkoxy-C 1-8 alkoxy, C 1-8 alkoxy-C 1-8 alkylthio, C 1-8 alkylthio-C 1-8 alkyl,C1-8 alkylthio- C1-8 alkoxy, C1-8 alkylthio-C1-8 alkylthio, C2-8 alkenyl and C2-8 alkyny
