STEFAN RALPH;PROHL SABINA;PRIES TANJA;TEVA PHARMACEUTICAL INDUSTRIES LTD.;MIKA HANS-JUERGEN;SCHENK DIRK
发明人:
STEFAN RALPH,PRIES TANJA,MIKA HANS-JUERGEN,SCHENK DIRK,PROHL SABINA
申请号：
IL24055715
公开号：
IL240557D0
申请日:
2015.08.13
申请国别(地区):
IL
年份:
2015
代理人:
摘要：
This invention provides a transdermal patch comprising a) a backing layer； b) a liner； c) optionally, a highly porous membrane； and d) a pharmaceutical composition comprising: (i) optionally, a pressure sensitive adhesive in an amount of up to about 95 wt % of the pharmaceutical composition, (ii) laquinimod in an amount of about 0.1-20 wt % of the pharmaceutical composition, and (iii) optionally, one or more permeation enhancers in a total amount of up to about 70 wt % of the pharmaceutical composition. This invention also provides a method for delivering laquinimod across the skin of the subject and for treating a human subject afflicted with a form of multiple sclerosis comprising administering to the skin of the subject a transdermal patch as described herein. This invention further provides a transdermal patch as described herein for use in treating a human subject afflicted with a form of multiple sclerosis.
