This invention provides a transdermal patch comprising: a) a backing layer； b) a liner； c) optionally, a highly porous membrane； and d) a pharmaceutical composition comprising: (i) optionally, a pressure sensitive adhesive in an amount of up to about 95 wt% of the pharmaceutical composition, (ii) laquinimod in an amount of about 0.1-20 wt% of the pharmaceutical composition, and (iii) optionally, one or more permeation enhancers in a total amount of up to about 70 wt% of the pharmaceutical composition. This invention also provides a method for delivering laquinimod across the skin of a subject and for treating a human subject afflicted with a form of multiple sclerosis comprising administering to the skin of the subject a transdermal patch as described herein. This invention further provides a transdermal patch as described herein for use in treating a human subject afflicted with a form of multiple sclerosis.
