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DERIVES DE 1,5-DIHYDRO-PYRAZOLO(3,4-D)PYRIMIDIN-4-ONE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE PDE9A POUR LE TRAITEMENT DE TROUBLES DU SNC
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
EICKMEIER, CHRISTIAN,DORNER-CIOSSEK, CORNELIA,FIEGEN, DENNIS,FOX, THOMAS,FUCHS, KLAUS,GIOVANNINI, RICCARDO,HEINE, NIKLAS,HENDRIX, MARTIN,ROSENBROCK, HOLGER,SCHAENZLE, GERHARD
申请号:
CA2706018
公开号:
CA2706018C
申请日:
2008.11.27
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
The invention relates to novel substituted pyrazolopyrimidines.Chemically, the compounds are characterised by general Formula (I): with R1being phenyl or pyridyl, any of which is substituted with 1 to 4, preferably 1to3 substituents X; X independently of each other being selected from C2-C6-alkylor Ci-C6-alkoxy, where C2-C6-alkyl and C1-C6-alkoxy are at least dihalogenatedup to perhalogenated. preferably with 2 to 6 halogen substituents, and thehalogenatoms being selected from the group of fluoro, chloro and bromo, preferablyfluoro; R2 being phenyl or heteroaryl, where phenyl is substituted by 1 to 3radicals and heteroaryl is optionally substituted by 1 to 3 radicals in eachcaseindependently of one another selected from the group of C1-C6-alkyI, C1-C6-alkoxy, hydroxycarbonyl, cyano, trifluoromethyl, amino, nitro, hydroxy, C1-C6-alkylamino, halogen, C6-C10-arylcarbonylamino,C1-C6-alkylcarbonylamino, C1- C6-alkylaminocarbonyl. C1-C6-alkoxycarbonyl, C6-C10-arylaminocarbonyl, heteroarylaminocarbonyl.heteroarylcarbonylamino, C1-C6-alkylsulphonyl- amino, C1-C6-alkylsulphonyl andC1-C6-alkylthio; The new compoundsshall be used for the manufacture of medicaments, in particular medicamentsfor improving, perception, concentration, learningand/or memory in patients in need thereof.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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