Board of Regents of the University of Texas System
发明人:
OLSON, ERIC,VAN ROOIJ, EVA
申请号：
PL07813595
公开号：
PL2056882T3
申请日:
2007.07.31
申请国别(地区):
PL
年份:
2013
代理人:
摘要：
The present invention relates to the identification of a microRNA, miR-208, that induces the expression of ²-myosin heavy chain (²-MHC) and represses fast skeletal muscle contractile protein genes. Inhibition of this function is proposed as a treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders.
