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RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN MICE
专利权人:
发明人:
申请号:
HK17112495.6
公开号:
HK1238672A
申请日:
2017.11.27
申请国别(地区):
HK
年份:
2018
代理人:
摘要:
Mice having a restricted immunoglobulin heavy chain locus are provided, wherein the locus is characterized by a single polymorphic human V H gene segment, a plurality of human D H gene segments and a plurality of J H gene segments. Methods for making antibody sequences that bind an antigen ( e.g ., a viral antigen) are provided, comprising immunizing a mouse with an antigen of interest, wherein the mouse comprises a single human V H gene segment, a plurality of human D H gene segments and a plurality of J H gene segments, at the endogenous immunoglobulin heavy chain locus.
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