MACDONALD, LYNN,MCWHIRTER, JOHN,GURER, CAGAN,MEAGHER, KAROLINA, A.,MURPHY, ANDREW, J.
申请号：
RSP20170893
公开号：
RS56458B1
申请日:
2012.10.17
申请国别(地区):
RS
年份:
2018
代理人:
摘要：
Mice having a restricted immunoglobulin heavy chain locus are provided, wherein the locus is characterized by a single polymorphic human V H gene segment, a plurality of human D H gene segments and a plurality of J H gene segments. Methods for making antibody sequences that bind an antigen ( e.g ., a viral antigen) are provided, comprising immunizing a mouse with an antigen of interest, wherein the mouse comprises a single human V H gene segment, a plurality of human D H gene segments and a plurality of J H gene segments, at the endogenous immunoglobulin heavy chain locus.
