Yamasa Corporation;National University Corporation Tokai National Higher Education and Research System
发明人:
申请号：
EP18873256.4
公开号：
EP3712160A1
申请日:
2018.10.31
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
To provide a nucleoside that is more practical for RNA pharmaceuticals and other applications and use thereof. A nucleoside derivative represented by formula (1) or (2) below, or a salt thereof.(In formula (1), R1 represents a hydrogen atom, a hydroxyl group, a hydroxyl group in which a hydrogen atom is substituted by an alkyl group or alkenyl group, or a protected group, and in formula (2), X represents a halogen atom. In formula (1) and formula (2), R2 and R3 may be the same or different, and each represents a hydrogen atom, a hydroxyl protecting group, a phosphate group, a protected phosphate group, or -P(=O)nR5R6 (in which n is 0 or 1, and R5 and R6 may be the same or different, with each representing a hydrogen atom, hydroxyl group, protected hydroxyl group, mercapto group, protected mercapto group, lower alkoxy group, cyano lower alkoxy group, amino group or substituted amino group, but when n is 1, R5 and R6 are not both hydrogen atoms), R4 represents NHR7 (in which R7 represents a hydrogen atom, an alkyl group, an alkenyl group or a protecting group for an amino group), an azide group, an amidino group or a guanidino group, each having a linking group, and B represent represents any of a purine-9-yl group, 2-oxo-pyrimidin-1-yl group, substituted purine-9-yl group or substituted 2-oxo-pyrimidin-1-yl group.)
