NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM;YAMASA CORPORATION
发明人:
UENO, YOSHIHITO,MAEDA, YUSUKE,KAJINO, RYOHEI
申请号：
CA3080896
公开号：
CA3080896A1
申请日:
2018.10.31
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Provided are: a nucleoside that is more suitable for practical use such as an RNA medicine or the like； and the use of the nucleoside. For this purpose, provided is a nucleoside derivative represented by formula (1) or (2) or a salt thereof. [Chem. 16] (In formula (1), R1 represents a hydrogen atom, a hydroxy group, a hydroxy group in which a hydrogen atom is substituted with an alkyl group or an alkenyl group, or a protected group, and in formula (2), X represents a halogen atom. In formula (1) and formula (2), R2 and R3 may be the same or different and each represent a hydrogen atom, a protecting group for a hydroxy group, a phosphate group, a protected phosphate group, or -P(=O)nR5R6 (n represents 0 or 1, R5 and R6 may be the same or different and each represent a hydrogen atom, a hydroxy group, a protected hydroxy group, a mercapto group, a protected mercapto group, a lower alkoxy group, a cyano lower alkoxy group, an amino group, or a substituted amino group. Note that when n is 1, R5 and R6 would not simultaneously be a hydrogen atom.), each R4 represents NHR7 having a linking group (R7 represents a hydrogen atom, an alkyl group, an alkenyl group, or a protecting group for amino group), an azide group, an amidino group, or a guanidino group, and B represents one of a purin-9-yl group, a 2-oxo-pyrimidin-1-yl group, a substituted purin-9-yl group, or a substituted 2-oxo-pyrimidin-1-yl group.)
