Arico, Beatrice Maria,Brunelli, Brunella,Comanducci, Maurizio,Pizza, Mariagrazia,Savino, Silvana,Scarselli, Maria
申请号：
AU2011384634
公开号：
AU2011384634A1
申请日:
2011.12.29
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. The compositions are adjuvanted with an aluminium phosphate adjuvant.
