A cryogenic storage bag for preserving various biological specimens at low temperatures for sustained periods. The storage bag comprises a plurality of storage compartments and a plurality of frangible tabs. At least two of the plurality of frangible tabs connect each of the plurality of storage compartments to an adjacent storage compartment. Each of the plurality of frangible tabs includes at least one notch and a narrowest portion located equidistant from at least two adjacent storage compartments. The at least one notch connects to walls of the at least two adjacent storage compartments utilizing a joining portion of each of the plurality of frangible tabs. The plurality of frangible tabs enables separation of the plurality of storage compartments from one another at cryogenic temperatures while retaining an effective hermetic integrity to each of the plurality of storage compartments.