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Zastosowanie mieszanin polimerów do wytwarzania powlekanych postaci leków oraz postaci leku z mieszaną powłoką polimerową
专利权人:
Evonik Röhm GmbH
发明人:
MEIER, CHRISTIAN,KNUPPEN, KARIN,PETEREIT, HANS-ULRICH
申请号:
PL06723193
公开号:
PL1890682T3
申请日:
2006.03.03
申请国别(地区):
PL
年份:
2017
代理人:
摘要:
The invention relates to the use of mixture of 2 to 60 wt. % of one or more polymers (I) with 40 to 98 wt. % of one or more polymers (II), whereby the polymer (I) is a (meth)acrylate copolymer, containing 90 to 100 wt. % radically polymerised of 40 to 95 wt. % of C<;SUB>;1 <;/SUB>;to C<;SUB>;4 <;/SUB>;alkyl esters of acrylic or methacrylic acid and 5 to 60 wt. % of units of (meth)acrylate monomers with an anionic group with 0 to 10 wt. % of further vinylic polymerisable monomers and polymer(ll) is a vinyl polymer different from polymer (I) or a polysaccharide or a derivative of a polysaccharide, containing 88 to 100 % neutral monomer units and up to 12 wt. % polymerisable monomer units with ionic groups, for production of a coated pharmaceutical formulation, containing an active agent core and a polymeric coating made from the mixture of polymers (I) and (II), characterised in that the glass temperature of polymer (I) is not more than 70° C. and an active agent release profile is achieved, whereby the agent release is delayed with relation to a pharmaceutical formulation with a coating made exclusively of polymer (I), starting with the same pH. The invention further relates to a pharmaceutical formulation with a selected polymer (I).
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