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UTILISATION DE MELANGES POLYMERES POUR LA PRODUCTION DE FORMES GALENIQUES ENROBEES ET FORME GALENIQUE AINSI OBTENUE
专利权人:
ROEHM GMBH
发明人:
MEIER, CHRISTIAN,KNUPPEN, KARIN,PETEREIT, HANS-ULRICH
申请号:
CA2606587
公开号:
CA2606587C
申请日:
2006.03.03
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
The invention relates to the use of mixture of 2 to 60 wt. % of one or morepolymers (I) with 40 to 98 wt. % of one or more polymers (II), whereby thepolymer (I) is a (meth)acrylate copolymer, containing 90 to 100 wt. %radically polymerised of 40 to 95 wt.% of C1 to C4 alkyl esters of acrylic ormethacrylic acid and 5 to 60 wt. % of units of (meth)acrylate monomers with ananionic group with 0 to 10 wt. % of further vinylic polymerisable monomers andpolymer(II) is a vinyl polymer different from polymer (I) or a polysaccharideor a derivative of a polysaccharide, containing 88 to 100 % neutral monomerunits and up to 12 wt. % polymerisable monomer units with ionic groups, forproduction of a coated pharmaceutical formulation, containing an active agentcore and a polymeric coating made from the mixture of polymers (I) and (II),characterised in that the glass temperature of polymer (I) is not more than 70~C and an active agent release profile is achieved, whereby the agent releaseis delayed with relation to a pharmaceutical formulation with a coating madeexclusively of polymer (I), starting with the same pH. The invention furtherrelates to a pharmaceutical formulation with a selected polymer (I).
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