GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
Rino Antonio Bit,John Alexander Brown,Philip G. Humphreys,Katherine Louise Jones
申请号：
US15559556
公开号：
US10442786B2
申请日:
2016.03.17
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Compounds of formula (I) and salts thereof:wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis； and cancers.
