Jerome F. Daanen,David A. DeGoey,Jennifer M. Frost,John R. Koenig,Steve Latshaw,Mark Matulenko,Marc Scanio,Lei Shi,William H. Bunnelle
申请号:
US14854433
公开号:
US09783527B2
申请日:
2015.09.15
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Compounds of formula (I)and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein A, R1 and R2 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.