Provided are compositions for and methods of treating a B-cell malignancy in a subject in need thereof, by administering to the subject a therapeutically effective amount of a combination comprising an inhibitor of a BTK inhibitor and a TLR inhibitor.本發明提供治療有需要之個體的B細胞惡性病之組合物及方法,其藉由投與該個體治療有效量之包含BTK抑制劑及TLR抑制劑之組合達成。