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DOSAGE FORM NIKOTINA
专利权人:
НИКОЧИНО АБ (SE)
发明人:
ХЮБИНЕТТЕ Фредрик (SE)
申请号:
RU2014143003
公开号:
RU2014143003A
申请日:
2013.03.15
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A mucoadhesive nicotine-containing film obtained by preparing an aqueous solution with a pH value of 9.5 to 13, said solution containing (i) a nicotine salt, (ii) an alkaline pH-regulating agent, and (iii) a film-forming agent containing alginate a monovalent cation or a mixture of alginates of monovalent cations, the film-forming agent having an average content of guluronate (G) from 50 to 85% by weight, an average content of mannuronate (M) from 15 to 50% by weight, and an average molecular weight from 30,000 g / mol to 90,000 g / mol, and is such that its 10% aq the solution at a temperature of 20 ° C has a viscosity of 100-1000 mPa · s, measured at a shear rate of 20 rpm on a Brookfield viscometer with spindle 2; - applying the solution to a solid surface; and - drying the solution on the specified surface. 2. The film according to claim 1, wherein the pH-adjusting agent is LiOH, NaOH or KOH. The film of claim 1, wherein the nicotine salt is an acid addition salt. The film of claim 3, wherein the acid addition salt is a tartaric acid salt. The film according to claim 1, further comprising a plasticizer. 6. The film of claim 1, further comprising a filler. 7. A film according to claim 1, having a thickness in the range from 0.01 mm to 2 mm. The film of claim 2, wherein the nicotine salt is an acid addition salt. The film of claim 8, wherein the acid addition salt is a tartaric acid salt. A film according to claim 2, further comprising a plasticizer. 11. The film of claim 2, further comprising a filler. 12. A film according to claim 2, having a thickness in the range from 0.01 mm to 2 mm. The unit dosage of nicotine, which is part of the film according to any one of paragraphs. 1-12.14. A dosage unit according to claim 13, having a surface area in the range of 2 to 8 cm. The dosage unit according to claim 13, having a nicotine content in the range from 0.5 mg to 4 m1. Мукоадгезивная никотинсодержащая пленка, полученная путем- приготовления водного раствора со з
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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