PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE AMINE DERIVATIVES

• 收藏
• 分享

专利权人:

Eigo Mutou;Shigeharu Sugisaki;Takashi Okada;Atsushi Inagaki;Shinichi Urayama

发明人:

Shinichi Urayama,Eigo Mutou,Atsushi Inagaki,Takashi Okada,Shigeharu Sugisaki

申请号：

US13325946

公开号：

US20120088826A1

申请日:

2011.12.14

申请国别(地区):

US

年份:

2012

代理人:

摘要：

An industrial process for production of high-purity optically active amine derivatives in high yield while inhibiting the formation of by-products, which comprises subjecting (E)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine to asymmetric reduction, catalytically reducing the obtained product at a reaction temperature of 40 to 100° C. and a pH of 3 to 9, subjecting the obtained (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine to propionylation, and then crystallizing the reaction mixture.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/