Recombinant AAV vectors expressing osteoprotective genes, including HAS2 and lubricin, useful in the treatment of osteoarthritis and related joint conditions in mammals
Dias Figueiredo, Monica,Kyostio-Moore, Sirkka R.M.,Berthelette, Patricia
申请号：
AU2017207917
公开号：
AU2017207917A1
申请日:
2017.01.13
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present disclosure relates to recombinant viral vectors, to pharmaceutical compositions comprising such recombinant vectors, and to methods for prevention and treatment of osteoarthritis in mammals. In particular, this disclosure provides adeno-associated virus (AAV) vectors capable of expressing, in a host, osteoprotective/chondroprotective bioactive proteins, including hyaluronan synthase 2 (HAS
