HERRMANN, FRANZISKA ELENA,NICKOLAUS, PETER,WOLLIN, STEFAN LUDWIG MICHAEL
申请号：
CA3079299
公开号：
CA3079299A1
申请日:
2018.10.12
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The application refers to a novel combination treatment/ combination medicament for PF-ILD treatment, comprising as a first combination partner a therapeutically effective amount of Nintedanib or a pharmaceutically acceptable salt thereof and as a second combination partner a therapeutically effective amount of a PDE4B -inhibitor of formula (I) wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is CI and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center or a pharmaceutically acceptable salt thereof. Hereby the second combination partner is preferably a therapeutically effective amount of the PDE4B-inhibitior of formula (III) or a pharmaceutically acceptable salt thereof.
