The objective of the present invention is to provide a ligand-binding fiber formed by immobilizing a ligand having an affinity with a cell membrane receptor on a fiber precursor, and to provide, using said ligand-binding fiber, a cell culture substrate with which amplification of cells expressing a specified cell membrane receptor can be carried out repeatedly in vitro. Provided is a ligand-binding fiber that includes a ligand having an affinity with a cell membrane receptor, and a fiber precursor being bound to said ligand.本發明之目的在於提供一種配體結合纖維及細胞培養基材，該配體結合纖維係將對細胞膜受體有親和性之配體固定於纖維前驅物而成，該細胞培養基材於生物體外反覆表現出特定細胞膜受體之細胞擴增。本發明之配體結合纖維包含對細胞膜受體有親和性之配體，及與該配體結合之纖維前驅物。
