ХАМБЛТОН Джули (US),БЛИМ Морин Р. (GB),ДЕЯНГ Морис П. (GB),ФЕРРОН-БРЭДИ Джералдин (GB),КУМАР Ракеш (GB),ОТТЕСЕН Лоун (GB)
申请号：
RU2015150233
公开号：
RU2015150233A
申请日:
2014.04.30
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
Methods of treating cancers comprising FGFR1 gene amplification, FGFR1 overexpression, FGFR3 overexpression, FGFR3 amplification, FGF2 overexpression, and/or FGF2 gene amplification are provided. In some embodiments, the methods comprise administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule. In some embodiments, the methods comprise administering a FGFR1 ECD and/or an FGFR1 ECD fusion molecule in combination with at least one additional therapeutic agent. In some embodiments, methods of treating cancers comprising administering a FGFR1 ECD and/or an FGFR1 ECD fusion molecule in combination with at least one chemotherapeutic agent are provided.
