The present disclosure relates to an apparatus for supporting acquisition of an area-of-interest in an ultrasound image. An apparatus for supporting acquisition of an area-of-interest in an ultrasound image according to an aspect of the present disclosure may comprise: at least one processor configured to convert coordinates of one or more areas-of-interest extracted from a first image to coordinates on a 3D model and collect the coordinates on the 3D model of the one or more areas-of-interest when a second image is acquired, calculate coordinates on the 3D model corresponding to the acquired second image and match the second image onto the 3D model including the coordinates of the collected areas-of-interest and provide guide information to allow acquisition of the collected areas-of-interest from the second image, using the matching result.