As for this invention, formula:[In formula, as for R as for shikuroarukiru and A the low-grade alkylene basis, as for connection between 3 rank and 4 ranks of the karubosuchiriru framework single connection or double bond is shown] to be something regarding the tetorazoriruarukokishi - jihidorokarubosuchiriru derivative or that salt and the combined use medicine which includes the combination of purobukoru, with the effect of the ride together sou peroxide inhibiter of the said combined use, for example the brain blockage (, for example the acutely brain blockage and the chronic brain blockage), the artery muscardine, the kidney disease (, the diabetes characteristic kidney symptom, kidney incompletion and the nephritis), and it is useful in prevention and remedy of diabetes.本発明は、式:[式中、Rはシクロアルキル基、Aは低級アルキレン基、カルボスチリル骨格の3位と4位間の結合は一重結合または二重結合を示す]のテトラゾリルアルコキシ-ジヒドロカルボスチリル誘導体またはその塩と、プロブコールの組合せを含む併用薬に関するものであり、該併用の相乗的なスーパーオキサイド抑制剤の効果により、脳梗塞(例えば、急性脳梗塞、慢性脳梗塞)、動脈硬化症、腎疾患(例えば、糖尿病性腎症、腎不全、腎炎)、および糖尿病の予防および治療に有用である。
