The present disclosure is directed to a method of treating prediabetes or type 1 or type 2 diabetes mellitus comprising administering to a subject in need thereof an effective amount of imeglimin, wherein the subject has chronic kidney disease.本發明係關於一種治療前期糖尿病或1型或2型糖尿病之方法,其包括向有需要之患者投與有效量之伊格列明(imeglimin),其中該患者患有慢性腎臟病。