SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF

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专利权人:

CEDARS-SINAI MEDICAL CENTER

发明人:

Joshua BREUNIG,Moise DANIELPOUR,Gi Bum KIM

申请号：

US16071407

公开号：

US20190390222A1

申请日:

2016.12.30

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Described herein are donor vectors and systems for use in in vivo dual recombinase-mediated cassette exchange. Also described are animal models for consistent, rigorous, and facile investigation of transgene expression. Further described are methods of screening for therapeutic drugs using these animal models, and methods of treatment

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